Proceedings (Mar 2024)
Post-GWAS Functional Analysis of the 11p11.2 Risk Locus Identifies <i>HSD17B12</i> as a Neuroblastoma Susceptibility Gene Involved in Lipid Metabolism
- Teresa Maiorino,
- Marianna Avitabile,
- Vito Alessandro Lasorsa,
- Annalaura Montella,
- Sueva Cantalupo,
- Matilde Tirelli,
- Martina Morini,
- Alessandra Eva,
- Marianna Caterino,
- Margherita Ruoppolo,
- John M. Maris,
- Sharon J. Diskin,
- Achille Iolascon,
- Mario Capasso
Affiliations
- Teresa Maiorino
- Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy
- Marianna Avitabile
- Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy
- Vito Alessandro Lasorsa
- CEINGE Biotecnologie Avanzate Franco Salvatore, 80131 Naples, Italy
- Annalaura Montella
- Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy
- Sueva Cantalupo
- Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy
- Matilde Tirelli
- CEINGE Biotecnologie Avanzate Franco Salvatore, 80131 Naples, Italy
- Martina Morini
- IRCCS Istituto G. Gaslini, 16147 Genoa, Italy
- Alessandra Eva
- IRCCS Istituto G. Gaslini, 16147 Genoa, Italy
- Marianna Caterino
- CEINGE Biotecnologie Avanzate Franco Salvatore, 80131 Naples, Italy
- Margherita Ruoppolo
- CEINGE Biotecnologie Avanzate Franco Salvatore, 80131 Naples, Italy
- John M. Maris
- The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
- Sharon J. Diskin
- The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
- Achille Iolascon
- Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy
- Mario Capasso
- Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy
- DOI
- https://doi.org/10.3390/proceedings2024100016
- Journal volume & issue
-
Vol. 100,
no. 1
p. 16
Abstract
Genome-wide association studies (GWASs) have contributed to the study of neuroblastoma (NB) genetics by identifying common risk variants that activate cancer-related processes associated with NB susceptibility [...]
Keywords
- genome-wide screening/GWAS
- neuroblastoma
- genetic predisposition
- functional genomics
- lipid metabolism
