Non-alcoholic fatty liver disease: prevalence, etiology, pathogenesis, approaches to the dіagnosis and therapy (literature review and own data)

Abstract

The article presents the modern literature data about the prevalence, etiology, pathogenesis of non-alcoholic fatty liver disease in type 2 diabetes mellitus, approaches to the diagnosis and therapy of these patients. The analysis of literature on the risk factors for cardiovascular diseases and cognitive impairment in patients with type 2 diabetes mellitus in non-alcoholic fatty liver disease has been carried out. The role of invasive, minimally invasive and non-invasive methods for assessing the degree of liver fibrosis is shown. The results of own researches, namely determining the features of melatonin excretion in urine and its correlation with the degree of liver fibrosis in patients with type 2 diabetes mellitus in the presence of non-alcoholic fatty liver disease, are given. The results of studying the level of adiponectin in these patients and the role of nutrient therapy to reduce the risk of cardiovascular disorders are presented.

Keywords

• type 2 diabetes mellitus
• non-alcoholic fatty liver disease
• cytokines
• adiponectin
• leptin
• resistin
• fibrosis mar-kers
• melatonin
• review