Cervical vestibular evoked myogenic potentials in 3-month-old infants: Comparative characteristics and feasibility for infant vestibular screening

Jiali Shen; Jiali Shen; Jiali Shen; Lu Wang; Lu Wang; Lu Wang; Xiaobao Ma; Xiaobao Ma; Xiaobao Ma; Zichen Chen; Jianyong Chen; Jianyong Chen; Jianyong Chen; Xueyan Wang; Kuan He; Kuan He; Kuan He; Wei Wang; Wei Wang; Wei Wang; Jin Sun; Jin Sun; Jin Sun; Qin Zhang; Qin Zhang; Qin Zhang; Min Shen; Min Shen; Min Shen; Xiangping Chen; Xiangping Chen; Xiangping Chen; Qing Zhang; Qing Zhang; Qing Zhang; Kimitaka Kaga; Maoli Duan; Maoli Duan; Jun Yang; Jun Yang; Jun Yang; Yulian Jin; Yulian Jin; Yulian Jin

doi:10.3389/fneur.2022.992392

Frontiers in Neurology (Sep 2022)

Cervical vestibular evoked myogenic potentials in 3-month-old infants: Comparative characteristics and feasibility for infant vestibular screening

Jiali Shen,
Jiali Shen,
Jiali Shen,
Lu Wang,
Lu Wang,
Lu Wang,
Xiaobao Ma,
Xiaobao Ma,
Xiaobao Ma,
Zichen Chen,
Jianyong Chen,
Jianyong Chen,
Jianyong Chen,
Xueyan Wang,
Kuan He,
Kuan He,
Kuan He,
Wei Wang,
Wei Wang,
Wei Wang,
Jin Sun,
Jin Sun,
Jin Sun,
Qin Zhang,
Qin Zhang,
Qin Zhang,
Min Shen,
Min Shen,
Min Shen,
Xiangping Chen,
Xiangping Chen,
Xiangping Chen,
Qing Zhang,
Qing Zhang,
Qing Zhang,
Kimitaka Kaga,
Maoli Duan,
Maoli Duan,
Jun Yang,
Jun Yang,
Jun Yang,
Yulian Jin,
Yulian Jin,
Yulian Jin

Affiliations

Jiali Shen: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jiali Shen: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jiali Shen: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Lu Wang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Lu Wang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Lu Wang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Xiaobao Ma: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Xiaobao Ma: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Xiaobao Ma: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Zichen Chen: Department of Otorhinolaryngology-Head and Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an, China
Jianyong Chen: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jianyong Chen: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jianyong Chen: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Xueyan Wang: Department of Otolaryngology-Head and Neck Surgery, Yanbian University Hospital, Yanji, China
Kuan He: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Kuan He: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Kuan He: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Wei Wang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Wei Wang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Wei Wang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Jin Sun: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jin Sun: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jin Sun: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Qin Zhang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Qin Zhang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Qin Zhang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Min Shen: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Min Shen: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Min Shen: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Xiangping Chen: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Xiangping Chen: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Xiangping Chen: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Qing Zhang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Qing Zhang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Qing Zhang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Kimitaka Kaga: National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
Maoli Duan: Ear Nose and Throat Patient Area, Trauma and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Sweden
Maoli Duan: Division of Ear, Nose, and Throat Diseases, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Jun Yang: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jun Yang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jun Yang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Yulian Jin: Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Yulian Jin: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Yulian Jin: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China

DOI: https://doi.org/10.3389/fneur.2022.992392
Journal volume & issue: Vol. 13

Abstract

Read online

ObjectiveWe compared the characteristics of air-conducted sound cervical vestibular evoked myogenic potential (ACS-cVEMP) and bone-conducted vibration cVEMP (BCV-cVEMP) among 3-month-old infants with normal hearing and sensorineural hearing loss (SNHL), and healthy adults to explore the feasibility and optimal strategies for infant vestibular screening.Methods29 infants (58 ears) were divided into two groups according to hearing (group I: normal hearing ears; group II: SNHL ears), 20 healthy adults were defined as group III. The results of response rate, P13 and N23 latency, P13-N23 interval, amplitudes, and corrected interaural asymmetry ratio (IAR) were recorded and compared among three groups.ResultsThe response rates of ACS-cVEMP in three groups were 88.89, 62.00, 100%, respectively. The P13 and N23 latencies, and P13-N23 interval did not differ significantly between group I and II (p = 0.866, p = 0.190, p = 0.252). A significant difference was found between group I and III (p = 0.016, p < 0.001, p < 0.001). No significant difference was observed in raw or corrected amplitude between group I and II (p = 0.741, p = 0.525), while raw and corrected amplitudes in group III were significantly larger than group I (p < 0.001, p < 0.001). For BCV-cVEMP, the response rates in three groups were 100, 86.36, 100%, respectively, No significant difference existed in the P13 and N23 latency, or P13-N23 interval between group I and II (p = 0.665, p = 0.925, p = 0.806), however, P13 and N23 latencies were significantly longer in group III than group I (p < 0.001, p = 0.018), but not in P13-N23 interval (p = 0.110). There was no significant difference in raw or corrected amplitude between group I and II (p = 0.771, p = 0.155) or in raw amplitude between group I and III (p = 0.093), however, a significant difference existed in corrected amplitude between group I and III (p < 0.001).ConclusionsCompared with adults, 3-month-old infants with normal hearing presented with equivalent response rates, shorter P13 and N23 latencies, smaller corrected amplitudes, and a wider IAR range for both ACS and BCV-cVEMP. SNHL infants had equivalent response rates of BCV-cVEMP, lower response rates of ACS-cVEMP than normal hearing infants. When responses were present, characteristics of ACS and BCV-cVEMP in SNHL infants were similar with normal hearing infants. ACS combined with BCV-cVEMP are recommended to improve the accuracy of vestibular screening.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

About the journal

Abstract

Keywords