Therapeutic effect of ketogenic diet treatment on type 2 diabetes

Fang Li; Yang Shen; Qun Chen; Xingyu Li; Hongnan Yang; Canyang Zhang; Jinjun Lin; Zhicheng Du; Chenyao Jiang; Chengming Yang; Dongmei Yu; Peiwu Qin

Journal of Future Foods (Jun 2022)

Therapeutic effect of ketogenic diet treatment on type 2 diabetes

Fang Li,
Yang Shen,
Qun Chen,
Xingyu Li,
Hongnan Yang,
Canyang Zhang,
Jinjun Lin,
Zhicheng Du,
Chenyao Jiang,
Chengming Yang,
Dongmei Yu,
Peiwu Qin

Affiliations

Fang Li: Institute of Bio-pharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518101, China
Yang Shen: Department of Endocrinology, Baoan Central Hospital of Shenzhen, the Fifth Affiliated Hospital of Shenzhen University, Shenzhen 518055, China
Qun Chen: Institute of Bio-pharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518101, China
Xingyu Li: Institute of Bio-pharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518101, China
Hongnan Yang: Department of Automation, Hangzhou Dianzi University, Hangzhou 310016, China
Canyang Zhang: Institute of Bio-pharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518101, China
Jinjun Lin: Department of Endocrinology, Baoan Central Hospital of Shenzhen, the Fifth Affiliated Hospital of Shenzhen University, Shenzhen 518055, China
Zhicheng Du: Institute of Bio-pharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518101, China
Chenyao Jiang: Institute of Bio-pharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518101, China
Chengming Yang: Southern University of Science and Technology Hospital, Shenzhen 518055, China
Dongmei Yu: Department of Electromechanical and Information Engineering, Shandong University, Weihai 264209, China; Corresponding authors.
Peiwu Qin: Institute of Bio-pharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518101, China; Corresponding authors.

Journal volume & issue: Vol. 2, no. 2
pp. 177 – 183

Abstract

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Diet plays an important role in diabetes development. The effect of ketogenic diet on type 2 diabetes remains elusive. In this study, we collect diabetes related physiological parameters and abdominal MRI images to evaluate the effect of ketogenic diet after 3-months of consecutive treatment. Ketogenic diet mitigates the diabetes symptom inferring from the statistically significant reduction of key diabetic physiological parameters such as Hemoglobin A1c (HbA1c) concentration, Triglyceride (TG), Fasting blood glucose (FBG), Body Mass Index (BMI), and adipose tissue volume. Moreover, we propose a new parameter to quantify the treating effect of ketogenic diet since Slope and Offset of Oral Glucose Tolerance Test (SOOGTT) incorporate more sampling points by fitting OGTT (Oral Glucose Tolerance Test) curve. SOOGTT shows statistically significant (P < 0.001) treating effect of ketogenic diet on type 2 diabetes. We use artificial intelligence to segment adipose tissue for treatment evaluation, which shows that ketogenic diet reduces the amount of adipose tissue.

Published in Journal of Future Foods

ISSN: 2772-5669 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Technology: Chemical technology: Food processing and manufacture
Website: https://www.keaipublishing.com/en/journals/journal-of-future-foods/

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