Frontiers in Nutrition (Sep 2022)
Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort: The EPIC study
- Fjorida Llaha,
- Valerie Cayssials,
- Valerie Cayssials,
- Valerie Cayssials,
- Marta Farràs,
- Antonio Agudo,
- Maria Sandström,
- Anne Kirstine Eriksen,
- Anne Tjønneland,
- Marie-Christine Boutron-Ruault,
- Nasser Laouali,
- Thérèse Truong,
- Charlotte Le Cornet,
- Verena Katzke,
- Matthias Schulze,
- Matthias Schulze,
- Domenico Palli,
- Vittorio Krogh,
- Simona Signoriello,
- Rosario Tumino,
- Fulvio Ricceri,
- Guri Skeie,
- Torill Miriam Enget Jensen,
- Sairah Lai Fa Chen,
- Cristina Lasheras,
- Miguel Rodriguez-Barranco,
- Miguel Rodriguez-Barranco,
- Miguel Rodriguez-Barranco,
- Pilar Amiano,
- Pilar Amiano,
- Pilar Amiano,
- José María Huerta,
- José María Huerta,
- Marcela Guevara,
- Marcela Guevara,
- Marcela Guevara,
- Martin Almquist,
- Lena Maria Nilson,
- Joakim Hennings,
- Keren Papier,
- Alicia Heath,
- Elisabete Weiderpass,
- Sabina Rinaldi,
- Raul Zamora-Ros
Affiliations
- Fjorida Llaha
- Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
- Valerie Cayssials
- Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
- Valerie Cayssials
- Department of Veterinary Public Health, Faculty of Veterinary, University of the Republic, Montevideo, Uruguay
- Valerie Cayssials
- Department of Quantitative Methods, Faculty of Medicine, University of the Republic, Montevideo, Uruguay
- Marta Farràs
- Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
- Antonio Agudo
- Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
- Maria Sandström
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
- Anne Kirstine Eriksen
- Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
- Anne Tjønneland
- Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
- Marie-Christine Boutron-Ruault
- University Paris-Saclay, University of Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut National de la Santé et de la Recherche Médicale (INSERM), Gustave Roussy, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Team “Exposome and Heredity”, Villejuif, France
- Nasser Laouali
- University Paris-Saclay, University of Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut National de la Santé et de la Recherche Médicale (INSERM), Gustave Roussy, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Team “Exposome and Heredity”, Villejuif, France
- Thérèse Truong
- University Paris-Saclay, University of Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut National de la Santé et de la Recherche Médicale (INSERM), Gustave Roussy, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Team “Exposome and Heredity”, Villejuif, France
- Charlotte Le Cornet
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
- Verena Katzke
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
- Matthias Schulze
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
- Matthias Schulze
- Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
- Domenico Palli
- 0Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - Institute for the Study and Prevention of Cancer, Florence, Italy
- Vittorio Krogh
- 1Epidemiology and Prevention Unit, Fondazione Istituto Nazionale dei Tumori (IRCCS), Milan, Italy
- Simona Signoriello
- 2Dipartimento di Salute Mentale e Fisica e Medicina Preventiva, Vanvitelli University, Naples, Italy
- Rosario Tumino
- 3Hyblean Association for Epidemiological Research (AIRE -ONLUS), Ragusa, Italy
- Fulvio Ricceri
- 4Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
- Guri Skeie
- 5Department of Community Medicine, Faculty of Health Sciences, University of Tromsø (UiT) - The Arctic University of Norway, Tromsø, Norway
- Torill Miriam Enget Jensen
- 5Department of Community Medicine, Faculty of Health Sciences, University of Tromsø (UiT) - The Arctic University of Norway, Tromsø, Norway
- Sairah Lai Fa Chen
- 5Department of Community Medicine, Faculty of Health Sciences, University of Tromsø (UiT) - The Arctic University of Norway, Tromsø, Norway
- Cristina Lasheras
- 6Department of Functional Biology. Medical School. University of Oviedo, Oviedo, Spain
- Miguel Rodriguez-Barranco
- 7Escuela Andaluza de Salud Pública, Granada, Spain
- Miguel Rodriguez-Barranco
- 8Instituto de Investigación Biosanitaria Granada (ibs.GRANADA), Granada, Spain
- Miguel Rodriguez-Barranco
- 9Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
- Pilar Amiano
- 9Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
- Pilar Amiano
- 0Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain
- Pilar Amiano
- 1Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain
- José María Huerta
- 9Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
- José María Huerta
- 2Department of Epidemiology, Murcia Regional Health Council, Biomedical Research Institute of Murcia (IMIB)-Arrixaca, Murcia, Spain
- Marcela Guevara
- 9Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
- Marcela Guevara
- 3Navarra Public Health Institute, Pamplona, Spain
- Marcela Guevara
- 4Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
- Martin Almquist
- 5Department of Surgery, Skåne University Hospital, Lund University, Lund, Sweden
- Lena Maria Nilson
- 6Department of Epidemiology and Global Health, Umeå University, Umeå, Sweden
- Joakim Hennings
- 7Department of Surgical and Perioperative Sciences/Surgery, Umeå University, Umeå, Sweden
- Keren Papier
- 8Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
- Alicia Heath
- 9Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
- Elisabete Weiderpass
- 0International Agency for Research on Cancer – World Health Organization (IARC-WHO), Lyon, France
- Sabina Rinaldi
- 0International Agency for Research on Cancer – World Health Organization (IARC-WHO), Lyon, France
- Raul Zamora-Ros
- Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
- DOI
- https://doi.org/10.3389/fnut.2022.982369
- Journal volume & issue
-
Vol. 9
Abstract
BackgroundThe Mediterranean diet (MD) has been proposed as a healthy diet with a potential to lower the incidence of several types of cancer, but there is no data regarding thyroid cancer (TC). We investigated the association between MD adherence, and its components, and the differentiated TC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.MethodsOver 450,000 men and women from nine European countries were followed up for a mean of 14.1 years, during which 712 differentiated TC cases were identified. Adherence to MD was estimated using the relative MD (rMED) score, an 18-point scale including alcohol, and the adapted rMED (arMED) score, a 16-point scale excluding alcohol. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors.ResultsAdherence to the arMED score was not associated with the risk of differentiated TC (HRhigh vs. low adherence = 0.94, 95% CI: 0.70–1.25; p-trend 0.27), while a suggestive, but non-statistically significant inverse relationship was observed with rMED (HRhigh vs. low adherence = 0.88, 95% CI: 0.68–1.14; p-trend 0.17). Low meat (HRlow vs. high meat intake = 0.81, 95% CI: 0.67–0.99; p-trend = 0.04) and moderate alcohol (HRmoderate vs. non−moderate intake = 0.88, 95% CI: 0.75–1.03) intake were related with lower differentiated TC risk.ConclusionsOur study shows that a high adherence to MD is not strongly related to differentiated TC risk, although further research is required to confirm the impact of MD and, especially, meat intake in TC risk.
Keywords