Nature Communications (Jun 2017)
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
- Kyungsoo Ha,
- Chengxian Ma,
- Han Lin,
- Lichun Tang,
- Zhusheng Lian,
- Fang Zhao,
- Ju-Mei Li,
- Bei Zhen,
- Huadong Pei,
- Suxia Han,
- Marcos Malumbres,
- Jianping Jin,
- Huan Chen,
- Yongxiang Zhao,
- Qing Zhu,
- Pumin Zhang
Affiliations
- Kyungsoo Ha
- National Center for Protein Sciences Beijing, Life Sciences Park
- Chengxian Ma
- Department of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College
- Han Lin
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Lichun Tang
- National Center for Protein Sciences Beijing, Life Sciences Park
- Zhusheng Lian
- Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College
- Fang Zhao
- National Center for International Research of Biological Targeting Diagnosis and Therapy, and Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University
- Ju-Mei Li
- Department of Biochemistry and Molecular Biology, University of Texas Health Sciences Center
- Bei Zhen
- National Center for Protein Sciences Beijing, Life Sciences Park
- Huadong Pei
- National Center for Protein Sciences Beijing, Life Sciences Park
- Suxia Han
- Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical College
- Marcos Malumbres
- Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3
- Jianping Jin
- Department of Biochemistry and Molecular Biology, University of Texas Health Sciences Center
- Huan Chen
- National Center for Protein Sciences Beijing, Life Sciences Park
- Yongxiang Zhao
- National Center for International Research of Biological Targeting Diagnosis and Therapy, and Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University
- Qing Zhu
- Department of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University Medical College
- Pumin Zhang
- National Center for Protein Sciences Beijing, Life Sciences Park
- DOI
- https://doi.org/10.1038/ncomms15751
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
The choice between homologous recombination and non-homologous end-joining is largely influenced by cell cycle. Here the authors show that APCCdh1 promotes homologous recombination by removing USP1, allowing polyubiquitinated histones to recruit BRCA1.
