Indian Journal of Pathology and Microbiology (Jan 2016)

'Childhood systemic mastocytosis associated with t (8; 21) (q22; q22) acute myeloid leukemia'

  • Nikhil Rabade,
  • Prashant Tembhare,
  • Nikhil Patkar,
  • Pratibha Amare,
  • Brijesh Arora,
  • P G Subramanian,
  • Sumeet Gujral

DOI
https://doi.org/10.4103/0377-4929.188140
Journal volume & issue
Vol. 59, no. 3
pp. 407 – 409

Abstract

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Systemic mastocytosis (SM) with associated clonal nonmast cell lineage disease is seen in up to 20% cases of SM. SM is uncommon in the pediatric population. T (8; 21) (q22; q22) is a good prognostic factor in acute myeloid leukemia (AML). However, the presence of SM confers poor prognosis in t (8; 21) (q22; q22) associated AML. We report the case of a child with t (8; 21) (q22; q22) associated AML with SM and her minimal residual disease status over the course of her treatment. In our case, the abnormal mast cells, showing co-expression of CD25 and CD2, persisted even after the marrow showed no evidence of residual AML.

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