Nature Communications (Nov 2019)

IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development

  • Iuliia O. Peshkova,
  • Turan Aghayev,
  • Aliia R. Fatkhullina,
  • Petr Makhov,
  • Elizaveta K. Titerina,
  • Satoru Eguchi,
  • Yin Fei Tan,
  • Andrew V. Kossenkov,
  • Marina V. Khoreva,
  • Lyudmila V. Gankovskaya,
  • Stephen M. Sykes,
  • Ekaterina K. Koltsova

DOI
https://doi.org/10.1038/s41467-019-13017-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Immune cells contribute to the aortic wall destruction during abdominal aortic aneurysm (AAA) development. Here, Peshkova et al. show that cytokine signaling through interleukin-27 receptor is required for Angiotensin II-induced myelopoiesis and mature myeloid cells production, thus contributing to their aortic accumulation and aneurysm progression