A lateral signalling pathway coordinates shape volatility during cell migration

Liang Zhang; Valbona Luga; Sarah K. Armitage; Martin Musiol; Amy Won; Christopher M. Yip; Sergey V. Plotnikov; Jeffrey L. Wrana

doi:10.1038/ncomms11714

Nature Communications (May 2016)

A lateral signalling pathway coordinates shape volatility during cell migration

Liang Zhang,
Valbona Luga,
Sarah K. Armitage,
Martin Musiol,
Amy Won,
Christopher M. Yip,
Sergey V. Plotnikov,
Jeffrey L. Wrana

Affiliations

Liang Zhang: Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Valbona Luga: Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Sarah K. Armitage: Department of Cell & Systems Biology, University of Toronto
Martin Musiol: Department of Cell & Systems Biology, University of Toronto
Amy Won: Department of Biochemistry, Institute of Biomaterials and Biomedical Engineering, The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
Christopher M. Yip: Department of Biochemistry, Institute of Biomaterials and Biomedical Engineering, The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
Sergey V. Plotnikov: Department of Cell & Systems Biology, University of Toronto
Jeffrey L. Wrana: Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital

DOI: https://doi.org/10.1038/ncomms11714
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Migrating cells display dynamic morphologies that are coordinated by signalling pathways. Here the authors identify a lateral signalling pathway, comprised of the planar cell polarity protein Pk1 and Arhgap21/23, that regulates fluctuations in cell shape during productive cell migration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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