Cerium doped TiO2 coating with superior antibacterial property and biocompatibility prepared by micro-arc oxidation

Shengcai Qi; Binbin Kang; Chao Yao; Dongmei Lan; Xiaohong Chen; Fengcang Ma; Ping Liu; Yuehua Liu

Materials & Design (Oct 2023)

Cerium doped TiO2 coating with superior antibacterial property and biocompatibility prepared by micro-arc oxidation

Shengcai Qi,
Binbin Kang,
Chao Yao,
Dongmei Lan,
Xiaohong Chen,
Fengcang Ma,
Ping Liu,
Yuehua Liu

Affiliations

Shengcai Qi: Department of Prosthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxill of Acial Development and Diseases, Fudan University, Shanghai, China; Medical College, Anhui University of Science and Technology, Huainan, China
Binbin Kang: School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China
Chao Yao: Department of Prosthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxill of Acial Development and Diseases, Fudan University, Shanghai, China; Medical College, Anhui University of Science and Technology, Huainan, China
Dongmei Lan: Department of Prosthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxill of Acial Development and Diseases, Fudan University, Shanghai, China; Medical College, Anhui University of Science and Technology, Huainan, China
Xiaohong Chen: School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China
Fengcang Ma: School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China
Ping Liu: School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China; Corresponding authors.
Yuehua Liu: Shanghai Key Laboratory of Craniomaxill of Acial Development and Diseases, Fudan University, Shanghai, China; Department of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Corresponding authors.

Journal volume & issue: Vol. 234
p. 112312

Abstract

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Peri-implantitis is a highly prevalent disease caused by bacterial plaque that results in inflammation. The disease starts from the soft tissue and gradually spreads to the hard tissue around the implant. If left untreated, it can lead to decreased bone density and loss of the implant. Therefore, it is crucial to improve the antibacterial and biological activity of implants to achieve dual functions. In this study, we prepared a Ce-doped TiO2 coating on the surface of pure titanium by micro-arc oxidation (MAO) for the prevention of peri-implantitis. We systematically investigated the physicochemical properties, antibacterial activity, and biocompatibility of Ce-doped coatings in vitro and in vivo. The results demonstrated that the increase of Ce concentration in the coating could increase the proliferation, adhesion and osteogenic differentiation of BMSCs in vitro. Results from in vivo osteogenesis experiments demonstrated that the 2Ce-MAO coating exhibited superior efficacy in promoting implant repair in osteoporotic rats. Furthermore, the results of in vitro and in vivo antibacterial experiments indicated that the Ce-TiO2 coating exhibits excellent antibacterial and anti-inflammatory properties. These findings suggest that the Ce-TiO2 coating prepared via MAO may be a promising approach for preventing peri-implantitis and promoting osteogenesis in osteoporosis.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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