Mechanical forces rewire metabolism in the tumor niche

Abstract

Tumor niche extracellular matrix stiffening and tumor cell metabolic reprogramming are two fundamental mediators of tumor progression. We recently elucidated a mechanistic interconnection between mechanotransduction and tumor metabolic rewiring in cancer. We demonstrated a stiffness-dependent amino acid crosstalk between stromal and cancer cells that fuels tumor progression and metastatic spreading.

Keywords

• cancer progression
• mechanotransduction
• yap/taz
• tumor cell metabolism
• cancer-associated fibroblast