Nature Communications (Oct 2022)

Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans

  • Chengjun Cao,
  • Keyi Wang,
  • Yina Wang,
  • Tong-Bao Liu,
  • Amariliz Rivera,
  • Chaoyang Xue

DOI
https://doi.org/10.1038/s41467-022-34151-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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The pathogenic yeast Cryptococcus neoformans forms large, so-called ‘titan cells’ during infection. Here, Cao et al. show that a ubiquitin ligase inhibits this process by targeting for degradation a CDK-related kinase that stimulates titan cell formation.