Communications Biology (Jan 2023)
Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas
- Nirmal Verma,
- Gopal Viswanathan Velmurugan,
- Edric Winford,
- Han Coburn,
- Deepak Kotiya,
- Noah Leibold,
- Laura Radulescu,
- Sanda Despa,
- Kuey C. Chen,
- Linda J. Van Eldik,
- Peter T. Nelson,
- Donna M. Wilcock,
- Gregory A. Jicha,
- Ann M. Stowe,
- Larry B. Goldstein,
- David K. Powel,
- Jeffrey H. Walton,
- Manuel F. Navedo,
- Matthew A. Nystoriak,
- Andrew J. Murray,
- Geert Jan Biessels,
- Claire Troakes,
- Henrik Zetterberg,
- John Hardy,
- Tammaryn Lashley,
- Florin Despa
Affiliations
- Nirmal Verma
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Gopal Viswanathan Velmurugan
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Edric Winford
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Han Coburn
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Deepak Kotiya
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Noah Leibold
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Laura Radulescu
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Sanda Despa
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Kuey C. Chen
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Linda J. Van Eldik
- Sanders-Brown Center on Aging, University of Kentucky
- Peter T. Nelson
- Sanders-Brown Center on Aging, University of Kentucky
- Donna M. Wilcock
- Sanders-Brown Center on Aging, University of Kentucky
- Gregory A. Jicha
- Sanders-Brown Center on Aging, University of Kentucky
- Ann M. Stowe
- Department of Neurology, University of Kentucky
- Larry B. Goldstein
- Department of Neurology, University of Kentucky
- David K. Powel
- Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky
- Jeffrey H. Walton
- NMR Facility, University of California
- Manuel F. Navedo
- Department of Pharmacology, University of California
- Matthew A. Nystoriak
- Department of Medicine, University of Louisville
- Andrew J. Murray
- Department of Physiology, Development and Neuroscience, University of Cambridge
- Geert Jan Biessels
- Department of Neurology, University Medical Center Utrecht
- Claire Troakes
- Basic and Clinical Neuroscience Department, King’s College London
- Henrik Zetterberg
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg
- John Hardy
- Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square
- Tammaryn Lashley
- Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square
- Florin Despa
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- DOI
- https://doi.org/10.1038/s42003-022-04398-2
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 16
Abstract
Converging data from humans and laboratory animals suggest that altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and Aβ pathology in Alzheimer’s disease brains.
