Nature Communications (Aug 2022)
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
- Sebastian Schmidt,
- Malte D. Luecken,
- Dietrich Trümbach,
- Sina Hembach,
- Kristina M. Niedermeier,
- Nicole Wenck,
- Klaus Pflügler,
- Constantin Stautner,
- Anika Böttcher,
- Heiko Lickert,
- Ciro Ramirez-Suastegui,
- Ruhel Ahmad,
- Michael J. Ziller,
- Julia C. Fitzgerald,
- Viktoria Ruf,
- Wilma D. J. van de Berg,
- Allert J. Jonker,
- Thomas Gasser,
- Beate Winner,
- Jürgen Winkler,
- Daniela M. Vogt Weisenhorn,
- Florian Giesert,
- Fabian J. Theis,
- Wolfgang Wurst
Affiliations
- Sebastian Schmidt
- Institute of Developmental Genetics, Helmholtz Zentrum München
- Malte D. Luecken
- Institute of Computational Biology, Helmholtz Zentrum München
- Dietrich Trümbach
- Institute of Developmental Genetics, Helmholtz Zentrum München
- Sina Hembach
- Institute of Developmental Genetics, Helmholtz Zentrum München
- Kristina M. Niedermeier
- Institute of Developmental Genetics, Helmholtz Zentrum München
- Nicole Wenck
- Institute of Developmental Genetics, Helmholtz Zentrum München
- Klaus Pflügler
- Institute of Developmental Genetics, Helmholtz Zentrum München
- Constantin Stautner
- Institute of Developmental Genetics, Helmholtz Zentrum München
- Anika Böttcher
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Heiko Lickert
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Ciro Ramirez-Suastegui
- Institute of Computational Biology, Helmholtz Zentrum München
- Ruhel Ahmad
- Max Planck Institute of Psychiatry
- Michael J. Ziller
- Department of Psychiatry, University of Münster
- Julia C. Fitzgerald
- Department of Neurodegenerative Diseases, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen
- Viktoria Ruf
- Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität Munich
- Wilma D. J. van de Berg
- Section Clinical Neuroanatomy and Biobanking (CNAB), Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam
- Allert J. Jonker
- Section Clinical Neuroanatomy and Biobanking (CNAB), Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam
- Thomas Gasser
- Department of Neurodegenerative Diseases, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen
- Beate Winner
- Department of Stem Cell Biology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
- Jürgen Winkler
- Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
- Daniela M. Vogt Weisenhorn
- Institute of Developmental Genetics, Helmholtz Zentrum München
- Florian Giesert
- Institute of Developmental Genetics, Helmholtz Zentrum München
- Fabian J. Theis
- Institute of Computational Biology, Helmholtz Zentrum München
- Wolfgang Wurst
- Institute of Developmental Genetics, Helmholtz Zentrum München
- DOI
- https://doi.org/10.1038/s41467-022-32229-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 25
Abstract
Here, the authors reveal using single-cell RNA sequencing that Parkinson’s disease (PD) patient-derived neuronal cells show altered primary cilia morphology and signaling suggesting cilia dysfunction may underlie PD pathogenesis.
