EFFECT OF POLYMORPHISMS FOR PAIRED LIKE HOMEODOMAIN 2 GENE ON SOME REPRODUCTIVE TRAITS IN GOAT

Abstract

The current research was detected at Agricultural Research Station/ ministry of Agriculture on 49 animals to clarify effect of paired like homeodomain transcription factor 2 (pitx2) gene on some reproductive traits as litter size, twining rate, fertility rate and revealing of polymorphisms for this gene. This study was founded four mutations in promoter region of pitx2 gene in different sites with appearance two dominant genotypes TT and GG with high effect on litter size due to each of C1141T and G1003A mutations with high litter size received to 1.48 and 1.57 born/ birth whilst G1089A and G1148A mutations not affect litter size, on another side, genotypes which refer to both mutations C1141T and G1003A influence on twining rate (p < 0.01). However, higher rate were for mutant genotypes CC and AA recorded 47.97% and 52.38% respectively while G1148A and G1089A and their genotypes did not affect the twining rate, moreover, genotypes within four single nucleated polymorphisms have an importance significantly (p < 0.01) on fertility rate which were more in local goat than Shami breed. Whereas, fertility rates were close to each other among different genotypes and lower rate belonging to GA heterozygous received 0.37 and 0.18 for native and Shami goats respectively. Values of Chi square for genetic and allelic frequencies tend up to 88.46 of GG refer to first and third mutations with higher allelic frequency for G, in the same side, frequencies were 0.50 and 0.648 due to TT and T as arrangement in spite of allelic frequency for A was declined to 0.060, 0.068 and 0.154 to G1148A and G1089A and G1003A sequentially.

Keywords

• gene
• genotypes
• goat
• paired like homeodomain 2
• reproduction