Nature Communications (Jun 2020)
Characterization of a pluripotent stem cell-derived matrix with powerful osteoregenerative capabilities
- Eoin P. McNeill,
- Suzanne Zeitouni,
- Simin Pan,
- Andrew Haskell,
- Michael Cesarek,
- Daniel Tahan,
- Bret H. Clough,
- Ulf Krause,
- Lauren K. Dobson,
- Mayra Garcia,
- Christopher Kung,
- Qingguo Zhao,
- W. Brian Saunders,
- Fei Liu,
- Roland Kaunas,
- Carl A. Gregory
Affiliations
- Eoin P. McNeill
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- Suzanne Zeitouni
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- Simin Pan
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- Andrew Haskell
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- Michael Cesarek
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- Daniel Tahan
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- Bret H. Clough
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- Ulf Krause
- Institute for Transfusion Medicine and Cellular Medicine, University Hospital Muenster
- Lauren K. Dobson
- Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University
- Mayra Garcia
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- Christopher Kung
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- Qingguo Zhao
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- W. Brian Saunders
- Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University
- Fei Liu
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- Roland Kaunas
- Department of Biomedical Engineering, Texas A&M University
- Carl A. Gregory
- Department of Molecular and Cellular Medicine, Institute for Regenerative Medicine, Texas A&M Health Science Center
- DOI
- https://doi.org/10.1038/s41467-020-16646-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Production of a safe and manufacturable material to mimic anabolic bone for tissue engineering has been hard to achieve to date. Here the authors use a mesenchymal stem cell line generated from induced pluripotent stem cells to produce osteogenic cell-matrix, displaying significant healing properties in mice.
