Frontiers in Immunology (Jan 2025)
From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments
- Zhenlin Li,
- Zhenlin Li,
- Zhenlin Li,
- Zhenlin Li,
- Fangqi Lu,
- Fangqi Lu,
- Fangqi Lu,
- Fangqi Lu,
- Fujin Zhou,
- Fujin Zhou,
- Fujin Zhou,
- Dekun Song,
- Dekun Song,
- Dekun Song,
- Lunhui Chang,
- Lunhui Chang,
- Lunhui Chang,
- Lunhui Chang,
- Weiying Liu,
- Guorong Yan,
- Guorong Yan,
- Guorong Yan,
- Guolong Zhang,
- Guolong Zhang,
- Guolong Zhang,
- Guolong Zhang
Affiliations
- Zhenlin Li
- School of Medicine, Anhui University of Science and Technology, Huainan, China
- Zhenlin Li
- Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Zhenlin Li
- Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Zhenlin Li
- Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
- Fangqi Lu
- School of Medicine, Anhui University of Science and Technology, Huainan, China
- Fangqi Lu
- Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Fangqi Lu
- Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Fangqi Lu
- Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
- Fujin Zhou
- School of Medicine, Anhui University of Science and Technology, Huainan, China
- Fujin Zhou
- Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Fujin Zhou
- Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Dekun Song
- School of Medicine, Anhui University of Science and Technology, Huainan, China
- Dekun Song
- Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Dekun Song
- Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Lunhui Chang
- School of Medicine, Anhui University of Science and Technology, Huainan, China
- Lunhui Chang
- Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Lunhui Chang
- Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Lunhui Chang
- Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
- Weiying Liu
- Department of Dermatology, Hunan Aerospace Hospital, Changsha, China
- Guorong Yan
- Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Guorong Yan
- Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Guorong Yan
- Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
- Guolong Zhang
- School of Medicine, Anhui University of Science and Technology, Huainan, China
- Guolong Zhang
- Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Guolong Zhang
- Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China
- Guolong Zhang
- Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
- DOI
- https://doi.org/10.3389/fimmu.2025.1518633
- Journal volume & issue
-
Vol. 16
Abstract
Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer, among which 82% arise from actinic keratosis (AK) characterized by lesions of epidermal keratinocyte dysplasia. It is of great significance to uncover the progression mechanisms from AK to cSCC, which will facilitate the early therapeutic intervention of AK before malignant transformation. Thus, more and more studies are trying to ascertain the potential transformation mechanisms through multi-omics, including genetics, transcriptomics, and epigenetics. In this review, we gave an overview of the specific biomarkers and signaling pathways that may be involved in the pathogenesis from AK to cSCC, pointing out future possible molecular therapies for the early intervention of AK and cSCC. We also discussed current interventions on AK and cSCC, together with future perspectives.
Keywords
- actinic keratosis
- cutaneous squamous cell carcinoma
- progression
- malignant transformation
- skin cancers
- non-melanoma skin cancers
