Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

Abstract

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.

Keywords

• L-carnitine
• molecular conjugation
• increased brain delivery
• prodrug
• nipecotic acid