Oxytetracycline versus Doxycycline Collagen Sponges Designed as Potential Carrier Supports in Biomedical Applications
Graţiela Teodora Tihan,
Ileana Rău,
Roxana Gabriela Zgârian,
Camelia Ungureanu,
Răzvan Constantin Barbaresso,
Mădălina Georgiana Albu Kaya,
Cristina Dinu-Pîrvu,
Mihaela Violeta Ghica
Affiliations
Graţiela Teodora Tihan
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania
Ileana Rău
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania
Roxana Gabriela Zgârian
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania
Camelia Ungureanu
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania
Răzvan Constantin Barbaresso
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania
Mădălina Georgiana Albu Kaya
Department of Collagen, Division Leather and Footwear Research Institute, National Research and Development Institute for Textile and Leather, 031215 Bucharest, Romania
Cristina Dinu-Pîrvu
Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 20956 Bucharest, Romania
Mihaela Violeta Ghica
Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 20956 Bucharest, Romania
Many research studies are directed toward developing safe and efficient collagen-based biomaterials as carriers for drug delivery systems. This article presents a comparative study of the properties of new collagen sponges prepared and characterized by different methods intended for biomedical applications. The structural integrity is one of the main properties for a biomaterial in order for it to be easily removed from the treated area. Thus, the effect of combining a natural polymer such as collagen with an antimicrobial drug such as oxytetracycline or doxycycline and glutaraldehyde as the chemical cross-linking agent influences the cross-linking degree of the material, which is in direct relation to its resistance to collagenase digestion, the drug kinetic release profile, and in vitro biocompatibility. The enzymatic degradation results identified oxytetracycline as the best inhibitor of collagenase when the collagen sponge was cross-linked with 0.5% glutaraldehyde. The drug release kinetics revealed an extended release of the antibiotic for oxytetracycline-loaded collagen sponges compared with doxycycline-loaded collagen sponges. Considering the behavior of differently prepared sponges, the collagen sponge with oxytetracycline and 0.5% glutaraldehyde could represent a viable polymeric support for the prevention/treatment of infections at the application site, favoring tissue regeneration.
