The data of TLR8 species specific downstream differentially regulated genes (DEGs)
Da Ao,
Jianzhong Zhu
Affiliations
Da Ao
Comparative Medicine Research Institute, Yangzhou University, China; College Veterinary Medicine, Yangzhou University, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, 225009, China
Jianzhong Zhu
Comparative Medicine Research Institute, Yangzhou University, China; College Veterinary Medicine, Yangzhou University, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, 225009, China; Corresponding author. Comparative Medicine Research Institute, Yangzhou University, China.
To compare porcine TLR8 (pTLR8) and human TLR8 (hTLR8) signaling pathways and downstream genes, we activated the pTLR8 and hTLR8 reporter cells with TLR8 agonist R848, and subjected the stimulated cells together with non-stimulated control cells for transcriptome analysis. There are 1157 differentially expression genes (DEGs) in R848 activated hTLR8 cells, whereas 502 DEGs in R848 activated pTLR8 cells. Among these DEGs, 804 genes are hTLR8 specific, 149 genes are pTLR8 specific, and 353 genes are hTLR8 and pTLR8 common. Related Results were published in reference [Ao, 2019]. Keywords: Toll-like receptor 8, R848, Porcine, DEGs
