Predictors of outcome in large vessel occlusion stroke patients with intravenous tirofiban treatment: a post hoc analysis of the RESCUE BT clinical trial
Xiang Liu,
Wencheng He,
Meiqiong Li,
Jie Yang,
Jiacheng Huang,
Weilin Kong,
Changwei Guo,
Jinrong Hu,
Shuai Liu,
Dahong Yang,
Jiaxing Song,
Zhouzhou Peng,
Linyu Li,
Yan Tian,
Wenjie Zi,
Chengsong Yue,
Fengli Li
Affiliations
Xiang Liu
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Wencheng He
Department of Neurology, Guangxi Guiping People’s Hospital
Meiqiong Li
Department of Neurology, Guangxi Guiping People’s Hospital
Jie Yang
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Jiacheng Huang
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Weilin Kong
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Changwei Guo
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Jinrong Hu
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Shuai Liu
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Dahong Yang
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Jiaxing Song
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Zhouzhou Peng
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Linyu Li
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Yan Tian
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Wenjie Zi
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Chengsong Yue
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Fengli Li
Department of Neurology, The Second Affiliated Hospital, Xinqiao Hospital, Army Medical University, Third Military Medical University
Abstract Objective The aim of this study was to investigate the factors influencing good outcomes in patients receiving only intravenous tirofiban with endovascular thrombectomy for large vessel occlusion stroke. Methods Post hoc exploratory analysis using the RESCUE BT trial identified consecutive patients who received intravenous tirofiban with endovascular thrombectomy for large vessel occlusion stroke in 55 comprehensive stroke centers from October 2018 to January 2022 in China. Results A total of 521 patients received intravenous tirofiban, 253 of whom achieved a good 90-day outcome (modified Rankin Scale [mRS] 0–2). Younger age (adjusted odds ratio [aOR]: 0.965, 95% confidence interval [CI]: 0.947–0.982; p < 0.001), lower serum glucose (aOR: 0.865, 95%CI: 0.807–0.928; p < 0.001), lower baseline National Institutes of Health Stroke Scale (NIHSS) score (aOR: 0.907, 95%CI: 0.869–0.947; p < 0.001), fewer total passes (aOR: 0.791, 95%CI: 0.665–0.939; p = 0.008), shorter punctures to recanalization time (aOR: 0.995, 95%CI:0.991–0.999; p = 0.017), and modified Thrombolysis in Cerebral Infarction (mTICI) score 2b to 3 (aOR: 8.330, 95%CI: 2.705–25.653; p < 0.001) were independent predictors of good outcomes after intravenous tirofiban with endovascular thrombectomy for large vessel occlusion stroke. Conclusion Younger age, lower serum glucose level, lower baseline NIHSS score, fewer total passes, shorter punctures to recanalization time, and mTICI scores of 2b to 3 were independent predictors of good outcomes after intravenous tirofiban with endovascular thrombectomy for large vessel occlusion stroke. Chinese clinical trial registry identifier ChiCTR-IOR-17014167.
