Frontiers in Immunology (Jan 2022)

Interleukins and Ischemic Stroke

  • Hua Zhu,
  • Hua Zhu,
  • Siping Hu,
  • Yuntao Li,
  • Yuntao Li,
  • Yao Sun,
  • Xiaoxing Xiong,
  • Xiaoxing Xiong,
  • Xinyao Hu,
  • Junjing Chen,
  • Sheng Qiu

DOI
https://doi.org/10.3389/fimmu.2022.828447
Journal volume & issue
Vol. 13

Abstract

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Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information transmission, activation and regulation of immune cells, mediating the activation, multiplication and differentiation of T and B cells and in the inflammatory reaction. Crosstalk between different ILs in different immune cells also impact the outcome of ischemic stroke. This overview is aimed to roughly discuss the multiple roles of ILs after ischemic stroke. The roles of IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12, IL-13, IL-15, IL-16, IL-17, IL-18, IL-19, IL-21, IL-22, IL-23, IL-32, IL-33, IL-34, IL-37, and IL-38 in ischemic stroke were discussed in this review.

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