CFC delta-beta is related with mixed features and response to treatment in bipolar II depression

Abstract

Objective: The aim of this study was to investigate whether differentiation of delta-beta cross frequency coupling (CFC) in bipolar II depressive episode with mixed features and consecutive remission was observed. Methods: 8 patient diagnosed bipolar disorder type II, depressive episode with mixed features according to DSM-V, were examined during the current episode, at baseline and end of the third week of lamotrigine use. Hamilton Depression Rating Scale (HDRS) and Mood Disorder Questionnaire (MDQ) were applied to each case at the baseline and end of the third week and QEEG was performed. Temperament was evaluated with TEMPS-A. Results: dPAC-DB and AAC-DB were significantly higher in FP2 at the end of 3rd weeks of lamotrigine use. A linear relationship was found between F3 dPAC-DB and MDQ scores, before and after treatment. P3 dPAC-DB was correlated with HDRS scores initially only. Cyclothymic temperament scores was found related with dPAC-DB and AAC-DB in F4. Conclusion: In bipolar disorder, delta-beta CFC was first investigated in this study. CFCs may have a neural projection of the physiopathology of bipolar disorder. At the point we reached in this study, we can show it as both state and trait.

Keywords

• Neuroscience
• Bipolar depression
• Mixed features
• QEEG
• Cross frequency coupling
• Treatment response to lamotrigine