Cancer Management and Research (Aug 2021)
Development and Validation of a Nomogram for Predicting Recurrence-Free Survival of Surgical Resected Retroperitoneal Liposarcoma
Abstract
Aobo Zhuang,1 Qian Wu,1 Hanxing Tong,1,2 Yong Zhang,1,2 Weiqi Lu1,2 1Department of General Surgery, South Hospital of Zhongshan Hospital/Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China; 2Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Weiqi Lu; Yong Zhang Email [email protected]; [email protected] and Objectives: Surgical treatment is still the mainstay of curative therapy for retroperitoneal liposarcoma (RLPS), but often recurs after surgical resection. We aimed to establish a nomogram for postoperative recurrence of RLPS based on the Asian population.Methods: Patients after surgical resection at the South Hospital of Zhongshan Hospital/Shanghai Public Health Clinical Center between August 2011 and December 2020 were included. The enrolled patients are randomly divided into training set and test set according to the ratio of 7:3. Prognostic factors were chosen based on Akaike Information Criterion, and the nomogram was built based on Cox regression and then internally validated through calibration plots and concordance index (C-index).Results: A total of 447 patients were included. Gender, age, presentation status, organ invasion and FNCLCC grade were used to build nomogram. The calibration plots showed that RFS predicted probabilities are identical to the actual RFS rates. The C-index of the nomogram was 0.703 (95% CI 0.623– 0.783) in the training set and 0.695 (95% CI 0.565– 0.825) in test set.Conclusion: The nomogram we established can accurately predict postoperative recurrence of RLPS patients for Asian population.Keywords: retroperitoneal soft tissue sarcoma, liposarcoma, recurrence, nomogram, surgery
