The Role of Interleukin-17 in Lung Cancer

Feng Wu; Juanjuan Xu; Qi Huang; Jieli Han; Limin Duan; Jinshuo Fan; Zhilei Lv; Mengfei Guo; Guorong Hu; Lian Chen; Shuai Zhang; Xiaonan Tao; Wanli Ma; Yang Jin

doi:10.1155/2016/8494079

Mediators of Inflammation (Jan 2016)

The Role of Interleukin-17 in Lung Cancer

Feng Wu,
Juanjuan Xu,
Qi Huang,
Jieli Han,
Limin Duan,
Jinshuo Fan,
Zhilei Lv,
Mengfei Guo,
Guorong Hu,
Lian Chen,
Shuai Zhang,
Xiaonan Tao,
Wanli Ma,
Yang Jin

Affiliations

Feng Wu: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Juanjuan Xu: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Qi Huang: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Jieli Han: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Limin Duan: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Jinshuo Fan: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Zhilei Lv: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Mengfei Guo: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Guorong Hu: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Lian Chen: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Shuai Zhang: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Xiaonan Tao: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Wanli Ma: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China
Yang Jin: Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China

DOI: https://doi.org/10.1155/2016/8494079
Journal volume & issue: Vol. 2016

Abstract

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Tumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associated tumours. Numerous studies have shown that IL-17 directly or indirectly promotes tumour angiogenesis and cell proliferation and that it inhibits apoptosis via the activation of inflammatory signalling pathways. Therefore, IL-17 contributes to the metastasis and progression of lung cancer. Research advances with respect to the role of IL-17 in lung cancer will be presented as a review in this paper.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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