BMC Geriatrics (Feb 2020)
Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of a quantitative observational study before and after routine clinical geriatric treatment – the ComOn-study
- Johanna Geritz,
- Sara Maetzold,
- Maren Steffen,
- Andrea Pilotto,
- Marta F. Corrà,
- Mariana Moscovich,
- Maria C. Rizzetti,
- Barbara Borroni,
- Alessandro Padovani,
- Annekathrin Alpes,
- Corinna Bang,
- Igor Barcellos,
- Ralf Baron,
- Thorsten Bartsch,
- Jos S. Becktepe,
- Daniela Berg,
- Lu M. Bergeest,
- Philipp Bergmann,
- Raquel Bouça-Machado,
- Michael Drey,
- Morad Elshehabi,
- Susan Farahmandi,
- Joaquim J. Ferreira,
- Andre Franke,
- Anja Friederich,
- Corinna Geisler,
- Philipp Hüllemann,
- Janne Gierthmühlen,
- Oliver Granert,
- Sebastian Heinzel,
- Maren K. Heller,
- Markus A. Hobert,
- Marc Hofmann,
- Björn Jemlich,
- Laura Kerkmann,
- Stephanie Knüpfer,
- Katharina Krause,
- Maximilian Kress,
- Sonja Krupp,
- Jennifer Kudelka,
- Gregor Kuhlenbäumer,
- Roland Kurth,
- Frank Leypoldt,
- Corina Maetzler,
- Luis F. Maia,
- Andreas Moewius,
- Patricia Neumann,
- Katharina Niemann,
- Christian T. Ortlieb,
- Steffen Paschen,
- Minh H. Pham,
- Thomas Puehler,
- Franziska Radloff,
- Christian Riedel,
- Marten Rogalski,
- Simone Sablowsky,
- Elena M. Schanz,
- Linda Schebesta,
- Andreas Schicketmüller,
- Simone Studt,
- Martina Thieves,
- Lars Tönges,
- Sebastian Ullrich,
- Peter P. Urban,
- Nuno Vila-Chã,
- Anna Wiegard,
- Elke Warmerdam,
- Tobias Warnecke,
- Michael Weiss,
- Julius Welzel,
- Clint Hansen,
- Walter Maetzler
Affiliations
- Johanna Geritz
- Department of Neurology, Christian-Albrechts-University of Kiel
- Sara Maetzold
- Department of Neurology, Christian-Albrechts-University of Kiel
- Maren Steffen
- Department of Neurology, Christian-Albrechts-University of Kiel
- Andrea Pilotto
- Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia
- Marta F. Corrà
- Neurology Department, Centro Hospitalar do Porto
- Mariana Moscovich
- Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná
- Maria C. Rizzetti
- Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia
- Barbara Borroni
- Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia
- Alessandro Padovani
- Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia
- Annekathrin Alpes
- Department of Neurology, Christian-Albrechts-University of Kiel
- Corinna Bang
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Igor Barcellos
- Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná
- Ralf Baron
- Department of Neurology, Christian-Albrechts-University of Kiel
- Thorsten Bartsch
- Department of Neurology, Christian-Albrechts-University of Kiel
- Jos S. Becktepe
- Department of Neurology, Christian-Albrechts-University of Kiel
- Daniela Berg
- Department of Neurology, Christian-Albrechts-University of Kiel
- Lu M. Bergeest
- Department of Neurology, Christian-Albrechts-University of Kiel
- Philipp Bergmann
- Department of Internal Medicine I, Christian-Albrechts-University of Kiel
- Raquel Bouça-Machado
- Instituto de Medicina Molecular, Lisbon, Portugal. CNS-Campus Neurológico Sénior, Torres Vedras, Portugal. Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon
- Michael Drey
- Medical Clinic and Policlinic IV, Ludwig-Maximilians-University of Munich
- Morad Elshehabi
- Department of Neurology, Christian-Albrechts-University of Kiel
- Susan Farahmandi
- Department of Neurology, Christian-Albrechts-University of Kiel
- Joaquim J. Ferreira
- Instituto de Medicina Molecular, Lisbon, Portugal. CNS-Campus Neurológico Sénior, Torres Vedras, Portugal. Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon
- Andre Franke
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Anja Friederich
- Department of Neurology, Christian-Albrechts-University of Kiel
- Corinna Geisler
- Institute of Human nutrition, Christian-Albrechts-University of Kiel
- Philipp Hüllemann
- Department of Neurology, Christian-Albrechts-University of Kiel
- Janne Gierthmühlen
- Department of Neurology, Christian-Albrechts-University of Kiel
- Oliver Granert
- Department of Neurology, Christian-Albrechts-University of Kiel
- Sebastian Heinzel
- Department of Neurology, Christian-Albrechts-University of Kiel
- Maren K. Heller
- Department of Neurology, Christian-Albrechts-University of Kiel
- Markus A. Hobert
- Department of Neurology, Christian-Albrechts-University of Kiel
- Marc Hofmann
- Hasomed GmbH
- Björn Jemlich
- Third Medical Clinic for Gastroenterology/Rheumatology, Städtisches Krankenhaus Kiel
- Laura Kerkmann
- Department of Neurology, Christian-Albrechts-University of Kiel
- Stephanie Knüpfer
- Department of Urology, Christian-Albrechts-University of Kiel
- Katharina Krause
- Department of Internal Medicine I, Christian-Albrechts-University of Kiel
- Maximilian Kress
- Department of Neurology, Christian-Albrechts-University of Kiel
- Sonja Krupp
- Research Group Geriatrics Lübeck, Red Cross Hospital Geriatric Centre
- Jennifer Kudelka
- Department of Neurology, Christian-Albrechts-University of Kiel
- Gregor Kuhlenbäumer
- Department of Neurology, Christian-Albrechts-University of Kiel
- Roland Kurth
- Department of Psychiatry and Psychotherapy, ZIP, Centre for Integrative Psychiatry
- Frank Leypoldt
- Department of Neurology, Christian-Albrechts-University of Kiel
- Corina Maetzler
- Department of Neurology, Christian-Albrechts-University of Kiel
- Luis F. Maia
- Neurology Department, Centro Hospitalar do Porto
- Andreas Moewius
- Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital
- Patricia Neumann
- Department of Neurology, Asklepios Klinik Barmbek
- Katharina Niemann
- Department of Neurology, Christian-Albrechts-University of Kiel
- Christian T. Ortlieb
- Department of Neurology, Christian-Albrechts-University of Kiel
- Steffen Paschen
- Department of Neurology, Christian-Albrechts-University of Kiel
- Minh H. Pham
- Department of Neurology, Christian-Albrechts-University of Kiel
- Thomas Puehler
- Department of Cardiac and Vascular Surgery, Universitätsklinikum Schleswig-Holstein Campus Kiel
- Franziska Radloff
- Department of Neurology, Christian-Albrechts-University of Kiel
- Christian Riedel
- Department of Radiology and Neuroradiology, Christian-Albrechts-University of Kiel
- Marten Rogalski
- Department of Neurology, Christian-Albrechts-University of Kiel
- Simone Sablowsky
- Department of Neurology, Christian-Albrechts-University of Kiel
- Elena M. Schanz
- Department of Neurology, Christian-Albrechts-University of Kiel
- Linda Schebesta
- Department of Neurology, Christian-Albrechts-University of Kiel
- Andreas Schicketmüller
- Hasomed GmbH
- Simone Studt
- Department of Psychiatry and Psychotherapy, ZIP, Centre for Integrative Psychiatry
- Martina Thieves
- Geriatric Clinic
- Lars Tönges
- Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital
- Sebastian Ullrich
- Third Medical Clinic for Gastroenterology/Rheumatology, Städtisches Krankenhaus Kiel
- Peter P. Urban
- Department of Neurology, Asklepios Klinik Barmbek
- Nuno Vila-Chã
- Neurology Department, Centro Hospitalar do Porto
- Anna Wiegard
- Department of Neurology, Christian-Albrechts-University of Kiel
- Elke Warmerdam
- Department of Neurology, Christian-Albrechts-University of Kiel
- Tobias Warnecke
- Department of Neurology, University Hospital Muenster
- Michael Weiss
- Department of Neurology, Christian-Albrechts-University of Kiel
- Julius Welzel
- Department of Neurology, Christian-Albrechts-University of Kiel
- Clint Hansen
- Department of Neurology, Christian-Albrechts-University of Kiel
- Walter Maetzler
- Department of Neurology, Christian-Albrechts-University of Kiel
- DOI
- https://doi.org/10.1186/s12877-020-1445-z
- Journal volume & issue
-
Vol. 20,
no. 1
pp. 1 – 13
Abstract
Abstract Background Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits, (ii) to investigate the interaction between both motor and cognitive deficits and (iii) to assess health status as well as treatment outcome of 1000 geriatric inpatients in hospitals of Kiel (Germany), Brescia (Italy), Porto (Portugal), Curitiba (Brazil) and Bochum (Germany). Methods This is a prospective, explorative observational multi-center study. In addition to the comprehensive geriatric assessment, quantitative measures of reduced mobility and motor and cognitive deficits are performed before and after a two week’s inpatient stay. Components of the assessment are mobile technology-based assessments of gait, balance and transfer performance, neuropsychological tests, frailty, sarcopenia, autonomic dysfunction and sensation, and questionnaires to assess behavioral deficits, activities of daily living, quality of life, fear of falling and dysphagia. Structural MRI and an unsupervised 24/7 home assessment of mobility are performed in a subgroup of participants. The study will also investigate the minimal clinically relevant change of the investigated parameters. Discussion This study will help form a better understanding of symptoms and their complex interactions and treatment effects in a large geriatric cohort.
Keywords
