Nature Communications (Jan 2022)

The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr/Ser(UCN) to optimise tRNA structure and mitochondrial translation

  • Nicole Kleiber,
  • Nicolas Lemus-Diaz,
  • Carina Stiller,
  • Marleen Heinrichs,
  • Mandy Mong-Quyen Mai,
  • Philipp Hackert,
  • Ricarda Richter-Dennerlein,
  • Claudia Höbartner,
  • Katherine E. Bohnsack,
  • Markus T. Bohnsack

DOI
https://doi.org/10.1038/s41467-021-27905-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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RNA modifications are key regulators of RNA functions. Here, the authors identify METTL8 as the enzyme installing m3C32 in mitochondrial tRNAThr/Ser(UCN). Lack of these modifications affects tRNA structure and impairs mitochondrial translation.