Nature Communications (Feb 2022)
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis
- Farshad Farshidfar,
- Kahn Rhrissorrakrai,
- Chaya Levovitz,
- Cong Peng,
- James Knight,
- Antonella Bacchiocchi,
- Juan Su,
- Mingzhu Yin,
- Mario Sznol,
- Stephan Ariyan,
- James Clune,
- Kelly Olino,
- Laxmi Parida,
- Joerg Nikolaus,
- Meiling Zhang,
- Shuang Zhao,
- Yan Wang,
- Gang Huang,
- Miaojian Wan,
- Xianan Li,
- Jian Cao,
- Qin Yan,
- Xiang Chen,
- Aaron M. Newman,
- Ruth Halaban
Affiliations
- Farshad Farshidfar
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Kahn Rhrissorrakrai
- IBM Research
- Chaya Levovitz
- IBM Research
- Cong Peng
- Xiangya Hospital, Central South University
- James Knight
- Yale Center for Genome Analysis, Yale University
- Antonella Bacchiocchi
- Department of Dermatology, Yale University School of Medicine
- Juan Su
- Xiangya Hospital, Central South University
- Mingzhu Yin
- Xiangya Hospital, Central South University
- Mario Sznol
- Department of Internal Medicine, Section of Medical Oncology, Yale University School of Medicine
- Stephan Ariyan
- Department of Surgery, Yale University School of Medicine
- James Clune
- Department of Surgery, Yale University School of Medicine
- Kelly Olino
- Department of Surgery, Yale University School of Medicine
- Laxmi Parida
- IBM Research
- Joerg Nikolaus
- Department of Molecular and Cellular Physiology, Yale University School of Medicine
- Meiling Zhang
- Department of Pathology, Yale University School of Medicine
- Shuang Zhao
- Xiangya Hospital, Central South University
- Yan Wang
- Department of Dermatologic Surgery Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College
- Gang Huang
- Department of Bone and Soft Tissue oncology, Hunan Cancer Hospital, Affiliated Tumor Hospital of Xiangya Medical School of Central South University
- Miaojian Wan
- Department of Dermatology, The Third Affiliated Hospital, Sun Yat-sen University
- Xianan Li
- Department of Bone and Soft Tissue oncology, Hunan Cancer Hospital, Affiliated Tumor Hospital of Xiangya Medical School of Central South University
- Jian Cao
- Department of Pathology, Yale University School of Medicine
- Qin Yan
- Department of Pathology, Yale University School of Medicine
- Xiang Chen
- Xiangya Hospital, Central South University
- Aaron M. Newman
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
- Ruth Halaban
- Department of Dermatology, Yale University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-28566-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Despite acral melanoma being the most common melanoma subtype in non-White individuals, its molecular drivers remain unknown. Here, the authors integrate genomic and clinical data from 104 patients and identify late-arising focal amplifications of chr22q11.21 and LZTR1 as a key tumour promoter in this region.
