Advances in the role of SIRT3-mediated mitochondrial function and metabolic regulation in diabetes mellitus type 2

Abstract

Diabetes mellitus type 2(T2DM) has a high morbidity because there is no specific treatment. Mitochondrial injury and metabolic disorder are the most important pathophysiological manifestations of T2DM. So it is essential to maintain mitochondrial function and cell metabolic homeostasis. Mitochondrial deacetylase silence information regulator 3 (SIRT3) is crucial for the regulation of respiratory enzymes, for antagonizing oxidative stress and promoting mitochondrial autophagy as well as glucose uptake.

Keywords

• sirt3|mitochondria|metabolism|diabetes mellitus type 2