BCL11A Promotes the Progression of Laryngeal Squamous Cell Carcinoma

Jian Zhou; Jian Zhou; Jian Zhou; Liang Zhou; Liang Zhou; Duo Zhang; Duo Zhang; Wei-Jing Tang; Wei-Jing Tang; Di Tang; Di Tang; Xiao-Ling Shi; Xiao-Ling Shi; Yue Yang; Yue Yang; Lin Zhou; Fei Liu; Yong Yu; Pentao Liu; Lei Tao; Lei Tao; Li-Ming Lu

doi:10.3389/fonc.2020.00375

Frontiers in Oncology (Mar 2020)

BCL11A Promotes the Progression of Laryngeal Squamous Cell Carcinoma

Jian Zhou,
Jian Zhou,
Jian Zhou,
Liang Zhou,
Liang Zhou,
Duo Zhang,
Duo Zhang,
Wei-Jing Tang,
Wei-Jing Tang,
Di Tang,
Di Tang,
Xiao-Ling Shi,
Xiao-Ling Shi,
Yue Yang,
Yue Yang,
Lin Zhou,
Fei Liu,
Yong Yu,
Pentao Liu,
Lei Tao,
Lei Tao,
Li-Ming Lu

Affiliations

Jian Zhou: Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jian Zhou: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
Jian Zhou: Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China
Liang Zhou: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
Liang Zhou: Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China
Duo Zhang: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
Duo Zhang: Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China
Wei-Jing Tang: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
Wei-Jing Tang: Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China
Di Tang: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
Di Tang: Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China
Xiao-Ling Shi: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
Xiao-Ling Shi: Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China
Yue Yang: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
Yue Yang: Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China
Lin Zhou: Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, China
Fei Liu: Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, China
Yong Yu: Wellcome Trust Sanger Institute, Cambridge, United Kingdom
Pentao Liu: Wellcome Trust Sanger Institute, Cambridge, United Kingdom
Lei Tao: Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
Lei Tao: Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China
Li-Ming Lu: Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fonc.2020.00375
Journal volume & issue: Vol. 10

Abstract

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Background: We report functional and clinical data uncovering the significance of B-cell lymphoma/leukemia 11A (BCL11A) in laryngeal squamous cell carcinoma (LSCC).Methods: We examined BCL11A expression in a cohort of LSCC patients and evaluated the association between BCL11A expression and clinicopathological features. We investigated the consequences of overexpressing BCL11A in the LSCC cell line on proliferation, migration, invasion, cell cycle, chemosensitivity, and growth in vivo. We explored the relationship between BCL11A and MDM2 in LSCC and tumorigenesis pathways by using the Human Cancer PathwayFinder Array.Results: High levels of BCL11A were found in LSCC tissues and were more frequently associated with advanced lymphatic metastasis stages with poor prognoses. BCL11A overexpression enhanced LSCC proliferation in vitro and vivo. A positive correlation between MDM2 and BCL11A expression was identified.Conclusions: These data uncover important functions of BCL11A in LSCC and identify BCL11A as a prognostic biomarker and potential therapeutic target in LSCC.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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