Breakthrough invasive candidiasis in pediatric patient with Ewing’s sarcoma: dinical case report and literature review

Abstract

We presented clinical case of invasive candidiasis in 13 years old girl with Ewing's sarcoma during intensive treatment with combined chemotherapy according EWING 2008 protocol. The most significant risk factors were recurrent chemotherapy induced neutropenia gr IV, multifocal Candida colonization, prolonged central venous catheter use, combined antibiotic therapy in the previous >10 days, parenteral nutrition. In spite of provided prophylaxis and antifungal therapy patient died because of progression of invasive candidiasis. We analyzed literature data on frequency of invasive candidiasis in children with Ewing's sarcoma and cases of breakthrough candidiasis in pediatric malignancies.

Keywords

• children
• oncology
• ewing's sarcoma
• chemotherapy
• candidiasis
• invasive mycosis
• echinocandins
• antifungal therapy