Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism
Elena E. Vaiman,
Natalia A. Shnayder,
Aiperi K. Khasanova,
Anna I. Strelnik,
Arseny J. Gayduk,
Mustafa Al-Zamil,
Margarita R. Sapronova,
Natalia G. Zhukova,
Daria A. Smirnova,
Regina F. Nasyrova
Affiliations
Elena E. Vaiman
V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Institute of Personalized Psychiatry and Neurology, 192019 St. Petersburg, Russia
Natalia A. Shnayder
V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Institute of Personalized Psychiatry and Neurology, 192019 St. Petersburg, Russia
Aiperi K. Khasanova
V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Institute of Personalized Psychiatry and Neurology, 192019 St. Petersburg, Russia
Anna I. Strelnik
International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, 443079 Samara, Russia
Arseny J. Gayduk
International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, 443079 Samara, Russia
Mustafa Al-Zamil
Department of Physiotherapy, Faculty of Continuing Medical Education, Peoples’ Friendship University of Russia, 117198 Moscow, Russia
Margarita R. Sapronova
Department of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education, V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
Natalia G. Zhukova
Department of Neurology and Neurosurgery, Siberian State Medical University, 634050 Tomsk, Russia
Daria A. Smirnova
International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, 443079 Samara, Russia
Regina F. Nasyrova
V. M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Institute of Personalized Psychiatry and Neurology, 192019 St. Petersburg, Russia
Among neurological adverse reactions in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other neurotransmitter systems. Presently, the development mechanisms remain poorly understood despite the presence of the considered theories of DIP pathogenesis.
