Enhanced bone regeneration with bioprinted GelMA/Bentonite scaffolds inspired by bone matrix

Jian Wang; Dongyang Zhou; Guangchao Wang; Miaomiao Wang; Fuxiao Wang; Yafei Han; Xiao Chen; Yan Hu; Fengjin Zhou; Zhongmin Shi; Xiaoxiang Ren; Jiacan Su

doi:10.1080/17452759.2024.2345765

Virtual and Physical Prototyping (Dec 2024)

Enhanced bone regeneration with bioprinted GelMA/Bentonite scaffolds inspired by bone matrix

Jian Wang,
Dongyang Zhou,
Guangchao Wang,
Miaomiao Wang,
Fuxiao Wang,
Yafei Han,
Xiao Chen,
Yan Hu,
Fengjin Zhou,
Zhongmin Shi,
Xiaoxiang Ren,
Jiacan Su

Affiliations

Jian Wang: Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
Dongyang Zhou: Institute of Translational Medicine, Shanghai University, Shanghai, People’s Republic of China
Guangchao Wang: Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
Miaomiao Wang: Institute of Translational Medicine, Shanghai University, Shanghai, People’s Republic of China
Fuxiao Wang: Institute of Translational Medicine, Shanghai University, Shanghai, People’s Republic of China
Yafei Han: Institute of Translational Medicine, Shanghai University, Shanghai, People’s Republic of China
Xiao Chen: Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
Yan Hu: Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
Fengjin Zhou: Department of Orthopedics, Honghui Hospital, Xi’an Jiao Tong University, Xi’an, People’s Republic of China
Zhongmin Shi: Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital, Shanghai, People’s Republic of China
Xiaoxiang Ren: Institute of Translational Medicine, Shanghai University, Shanghai, People’s Republic of China
Jiacan Su: Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

DOI: https://doi.org/10.1080/17452759.2024.2345765
Journal volume & issue: Vol. 19, no. 1

Abstract

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ABSTRACTIn bone tissue engineering, the search for improved repair methods is crucial, given the drawbacks of traditional strategies like donor site issues and immune rejection. Addressing these challenges, this paper introduces an innovative GelMA/Bentonite composite bioink for 3D bioprinting, designed to create scaffolds that closely emulate native bone tissue. GelMA is selected for its biocompatibility and modifiable mechanics, while Bentonite's mineral richness and ion exchange capacity are harnessed to enhance scaffold structure and promote an osteogenic microenvironment. This research marks the inaugural incorporation of Bentonite into a bioink, a significant stride forward given its established safety in pharmaceuticals and versatility across industries. This bioink formulation signifies a breakthrough in bone tissue engineering, aiming to improve the osteointegration and regeneration of bone tissue. Combining Bentonite with GelMA marks a key step in creating bioinks that enhance bone healing, potentially transforming scaffold-based bone regeneration and pioneering the use of natural nanomaterials in medicine.

Published in Virtual and Physical Prototyping

ISSN: 1745-2759 (Print); 1745-2767 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Science; Technology: Manufactures
Website: https://www.tandfonline.com/nvpp

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