GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation

Takahiro Suzuki; Erina Furuhata; Shiori Maeda; Mami Kishima; Yurina Miyajima; Yuki Tanaka; Joanne Lim; Hajime Nishimura; Yuri Nakanishi; Aiko Shojima; Harukazu Suzuki

doi:10.1038/s42003-022-03365-1

Communications Biology (May 2022)

GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation

Takahiro Suzuki,
Erina Furuhata,
Shiori Maeda,
Mami Kishima,
Yurina Miyajima,
Yuki Tanaka,
Joanne Lim,
Hajime Nishimura,
Yuri Nakanishi,
Aiko Shojima,
Harukazu Suzuki

Affiliations

Takahiro Suzuki: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus
Erina Furuhata: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus
Shiori Maeda: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus
Mami Kishima: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus
Yurina Miyajima: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus
Yuki Tanaka: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus
Joanne Lim: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus
Hajime Nishimura: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus
Yuri Nakanishi: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus
Aiko Shojima: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus
Harukazu Suzuki: Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrated Medical Science (IMS), RIKEN Yokohama Campus

DOI: https://doi.org/10.1038/s42003-022-03365-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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An integrated analysis of human induced pluripotent stem cells differentiating into hepatocyte-like cells unveils changes in DNA methylation and relevant transcription factors (like GATA6) that may influence hepatic development.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal