Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds
Vladimir Kanygin,
Ivan Razumov,
Alexander Zaboronok,
Evgenii Zavjalov,
Aleksandr Kichigin,
Olga Solovieva,
Alphiya Tsygankova,
Tatiana Guselnikova,
Dmitrii Kasatov,
Tatiana Sycheva,
Bryan J. Mathis,
Sergey Taskaev
Affiliations
Vladimir Kanygin
Laboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia
Ivan Razumov
Laboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia
Alexander Zaboronok
Laboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia
Evgenii Zavjalov
Laboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia
Aleksandr Kichigin
Laboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia
Olga Solovieva
Laboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia
Alphiya Tsygankova
Laboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia
Tatiana Guselnikova
Laboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia
Dmitrii Kasatov
Laboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia
Tatiana Sycheva
Budker Institute of Nuclear Physics, Siberian Branch of Russian Academy of Sciences, 11, Acad. Lavrentieva Ave., 630090 Novosibirsk, Russia
Bryan J. Mathis
International Medical Center, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba 305-8576, Ibaraki, Japan
Sergey Taskaev
Budker Institute of Nuclear Physics, Siberian Branch of Russian Academy of Sciences, 11, Acad. Lavrentieva Ave., 630090 Novosibirsk, Russia
(1) Background: Developments in accelerator-based neutron sources moved boron neutron capture therapy (BNCT) to the next phase, where new neutron radiation parameters had to be studied for the treatment of cancers, including brain tumors. We aimed to further improve accelerator-BNCT efficacy by optimizing dosimetry control, beam parameters, and combinations of boronophenylalanine (BPA) and sodium borocaptate (BSH) administration in U87MG xenograft-bearing immunodeficient mice with two different tumor locations. (2) Methods: The study included two sets of experiments. In Experiment #1, BPA only and single or double irradiation in higher doses were used, while, in Experiment #2, BPA and BSH combinations and single or double irradiation with dosage adjustment were analyzed. Mice without treatment or irradiation after BPA or BPA+BSH injection were used as controls. (3) Results: Irradiation parameter adjustment and BPA and BSH combination led to 80–83% tumor-growth inhibition index scores, irradiation:BNCT ratios of 1:2, and increases in animal life expectancy from 9 to 107 days. (4) Conclusions: Adjustments in dosimetry control, calculation of irradiation doses, and combined use of two 10B compounds allowed for BNCT optimization that will be useful in the development of clinical-trial protocols for accelerator-based BNCT.
