Nature Communications (Nov 2019)

KRAS regulation by small non-coding RNAs and SNARE proteins

  • Yonglu Che,
  • Zurab Siprashvili,
  • Joanna R. Kovalski,
  • Tiffany Jiang,
  • Glenn Wozniak,
  • Lara Elcavage,
  • Paul A. Khavari

DOI
https://doi.org/10.1038/s41467-019-13106-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Small nucleolar RNAs, SNORD50A/B are frequently deleted in cancers and can inhibit KRAS but by unclear means. Here, the authors show that KRAS trafficking and enrichment on the plasma membrane is mediated by SNARE vesicle transport proteins and that SNORD50A/B compete with these proteins to antagonise these effects.