Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization

Abstract

In this paper, we demonstrate the application of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique to rapid and selective crystallization of a small drug compound. i.e. acetaminophen. Subsequent characterization of the crystals by optical microscopy, powder X-ray diffraction (PXRD) and Raman spectroscopy showed quantitatively selective growth of different crystal forms at various experimental conditions. Acetaminophen crystals were grown predominantly as Form Ⅰ (99%) on blank glass slides at room temperature. Form Ⅱ crystals with 39% purity grown on SIFs using microwave energy.

Keywords

• metal-assisted and microwave-accelerated evaporative crystallization
• crystallization
• acetaminophen
• silver nanoparticles