mBio (Jun 2021)

Mechanisms of Transforming DNA Uptake to the Periplasm of Bacillus subtilis

  • Jeanette Hahn,
  • Micaela DeSantis,
  • David Dubnau

DOI
https://doi.org/10.1128/mBio.01061-21
Journal volume & issue
Vol. 12, no. 3

Abstract

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Transformation is a widely distributed mechanism of bacterial horizontal gene transfer that plays a role in the spread of antibiotic resistance and virulence genes and more generally in evolution. Although transformation was discovered nearly a century ago and most, if not all the proteins required have been identified in several bacterial species, much remains poorly understood about the molecular mechanism of DNA uptake.