3D-printed, citrate-based bioresorbable vascular scaffolds for coronary artery angioplasty

Yonghui Ding; Liam Warlick; Mian Chen; Eden Taddese; Caralyn Collins; Rao Fu; Chongwen Duan; Xinlong Wang; Henry Ware; Cheng Sun; Guillermo Ameer

Bioactive Materials (Aug 2024)

3D-printed, citrate-based bioresorbable vascular scaffolds for coronary artery angioplasty

Yonghui Ding,
Liam Warlick,
Mian Chen,
Eden Taddese,
Caralyn Collins,
Rao Fu,
Chongwen Duan,
Xinlong Wang,
Henry Ware,
Cheng Sun,
Guillermo Ameer

Affiliations

Yonghui Ding: Centre for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL 60208, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
Liam Warlick: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA
Mian Chen: Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
Eden Taddese: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA
Caralyn Collins: Centre for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA
Rao Fu: Centre for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA
Chongwen Duan: Centre for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL 60208, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
Xinlong Wang: Centre for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL 60208, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
Henry Ware: Centre for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA
Cheng Sun: Centre for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA; Corresponding author. Centre for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL, 60208, USA.
Guillermo Ameer: Centre for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL 60208, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Corresponding author. Centre for Advanced Regenerative Engineering (CARE), Northwestern University, Evanston, IL, 60208, USA.

Journal volume & issue: Vol. 38
pp. 195 – 206

Abstract

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Fully bioresorbable vascular scaffolds (BVSs) aim to overcome the limitations of metallic drug-eluting stents (DESs). However, polymer-based BVSs, such as Abbott's Absorb, the only US FDA-approved BVS, have had limited use due to increased strut thickness (157 μm for Absorb), exacerbated tissue inflammation, and increased risk of major cardiac events leading to inferior clinical performance when compared to metallic DESs. Herein we report the development of a drug-eluting BVS (DE-BVS) through the innovative use of a photopolymerizable, citrate-based biomaterial and a high-precision additive manufacturing process. BVS with a clinically relevant strut thickness of 62 μm can be produced in a high-throughput manner, i.e. one BVS per minute, and controlled release of the anti-restenosis drug everolimus can be achieved by engineering the structure of polymer coatings to fabricate drug-eluting BVS. We achieved the successful deployment of BVSs and DE-BVSs in swine coronary arteries using a custom-built balloon catheter and BVS delivery system and confirmed BVS safety and efficacy regarding maintenance of vessel patency for 28 days, observing an inflammation profile for BVS and DE-BVS that was comparable to the commercial XIENCE™ DES (Abbott Vascular).

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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