Sub-acute toxicity profile of methanolic leaf extract of Securidaca longipedunculata in rats

Abstract

This study investigates the toxicological profile of Securidaca longipedunculatain rats. Sub- acute toxicity study was conducted by oral administration of the extracts to rats at daily doses of 25, 50 and 100mg/kg body weight for 28 days. Methanol leaf extract of S. longipedunculata caused significant (p 0.05) difference in serum aspartate transaminase (AST), alanine transaminase (ALT), potassium, triglyceride albumin and bilirubin concentration when compared with control. Jobelyn and dexamethazone caused significant (p0.05) effect on hematological parameters except for a significant increase (p<0.05) in white blood cells when compared with the normal control. The plant extracts have shown no serious adverse effect on hematological and biochemical parameters. Thus, S. longipedunculata methanol leaf extract could be considered as a natural source of antibiotics for therapeutic purposes.

Keywords

• dexamethasone,
• therapeutic,
• hematological,
• Securidaca,
• longipedunculata