Xin yixue (Mar 2023)

Blastic plasmacytoid dendritic cell neoplasm complicated with acute myeloid leukemia: a case report

  • Kong Lihua, Qin Lili, Feng Anhua, Liu Zhenzhen, Tang Na, Zang Jikang, Wang Haiying

DOI
https://doi.org/10.3969/j.issn.0253-9802.2023.03.010
Journal volume & issue
Vol. 54, no. 3
pp. 216 – 220

Abstract

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Blastic plasmacytoid dendritic cell neoplasm （BPDCN） complicated with acute myeloid leukemia （AML） is a rare disease. In this article， we reported the diagnosis and treatment of one patient of BPDCN complicated with AML who presented with fever as the first symptom， aiming to enhance the diagnostic and therapeutic capability of clinicians for this disease. The male patient， aged 69 years old， was admitted to hospital due to fever for 1 week. He had no typical skin lesions. Morphological and cytological observation of bone marrow smear showed extremely active hyperplasia and tumor cells with specific immunophenotype. The diagnosis of BPDCN complicated with AML was confirmed. A low-intensity venetoclax-based chemotherapy regimen was recommended. However， the patient discontinued further treatment.

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