Zhongguo quanke yixue (Mar 2024)
Correlation of Platelet Distribution Width with Different Hypertension Subtypes in Elderly Males and Females
Abstract
Background In recent years, the prevalence of hypertension among the elderly in China has been consistently increasing. Current studies have found some association between hypertension and platelets, and platelet distribution width serves as the most sensitive measure of platelet activation, therefore, this study was conducted to explore the relationship between platelet distribution width and hypertension in elderly males and females. Objective To investigate the correlation of platelet distribution width with various hypertension subtypes in the elderly males and females. Methods A total of 600 elderly hypertensive and elderly non-hypertensive patients aged 65 years and above who were hospitalized in the Department of Cardiovascular Medicine, Hebei Provincial People's Hospital between 1 January 2020 and 24 April 2023 were consecutively enrolled and classified into 150 cases in the simple systolic hypertension (ISH) group, 150 cases in the simple diastolic hypertension (IDH) group, 150 cases in the systolic-diastolic hypertension (SDH) group, 150 cases in the normotensive group based on hypertension measurements. Basic data of patients were collected, including age, gender, BMI, systolic blood pressure, diastolic blood pressure, creatinine, uric acid, total cholesterol, triacylglycerol, high-density lipoprotein cholesterol (HDL-C) , low-density lipoprotein cholesterol (LDL-C) , fasting blood glucose, and platelet distribution width. Binary Logistic regression models were used to analyze the correlation between platelet distribution width and different hypertension subtypes. Results Binary Logistic regression analysis showed that age, uric acid, and platelet distribution width were influencing factors in the occurrence of ISH in males (P<0.05) ; age, BMI, total cholesterol, triacylglycerol, HDL-C, LDL-C, and platelet distribution width were influencing factors in the occurrence of IDH in males (P<0.05) . Moreover, BMI, uric acid, total cholesterol, triacylglycerol, HDL-C, LDL-C, platelet distribution width, and fasting blood glucose were identified as influencing factors in the occurrence of SDH in males (P<0.05) . BMI, total cholesterol, triacylglycerol, and platelet distribution width were influencing factors in the occurrence of ISH females (P<0.05) . BMI, triacylglycerol, HDL-C, and platelet distribution width were influencing factors in the occurrence of IDH in women (P<0.05) . BMI, total cholesterol, HDL-C, LDL-C, and platelet distribution width were influencing factors for the occurrence of SDH in women (P<0.05) . The sex-stratified analysis showed that, after adjusting for confounders such as age, BMI, creatinine, uric acid, total cholesterol, triacylglycerol, HDL-C, LDL-C, and fasting blood glucose, in males, the quartile 3 of platelet distribution width (>12.1-12.9 fL) was a risk factor for ISH (OR=8.893, 95%CI=2.731-28.955) , IDH (OR=5.265, 95%CI=1.758-15.768) , and SDH (OR=4.674, 95%CI=1.549-14.102) , while the quartile 4 of platelet distribution width (>12.9 fL) was a risk factor in the occurrence of SDH (OR=3.316, 95%CI=1.177-9.345) compared to quartile 1 of platelet distribution width (≤10.7 fL) ; in females, compared to quartile 1 of platelet distribution width (≤11.0 fL) , the quartile 3 of platelet distribution width (>12.4-13.2 fL) was a risk factor for ISH (OR=3.494, 95%CI=1.218-10.021) and SDH (OR=4.949, 95%CI=1.283-19.089) , quartile 4 of platelet distribution width (>13.2 fL) was a risk factor for ISH (OR=5.283, 95%CI=1.786-15.633) , IDH (OR=5.837, 95%CI=1.544-22.068) and SDH (OR=4.966, 95%CI=1.373-17.963) . Conclusion Among elderly males, platelet distribution width ≥12.1 fL is a risk factor for IDH and SDH. Among elderly women, platelet distribution width ≥12.4 fL is a risk factor for ISH and SDH, when platelet distribution width>13.2 fL, it is a risk factor for IDH.
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