Cohort profile: the Chinese Pregnant Women Cohort Study and Offspring Follow-up (CPWCSaOF)

Xuan Liu; Guangliang Shan; Ping Huang; Yu Jiang; Yimin Qu; Jian Zhao; Tianchen Lyu; Yunli Chen; Yongle Zhan; Yingjie Shi; Hexin Yue; Yaohan Meng; Ao Jing; Haihui Ma; Dongmei Man; Xiaoxiu Li; Hongguo Wu

doi:10.1136/bmjopen-2020-044933

BMJ Open (Mar 2021)

Cohort profile: the Chinese Pregnant Women Cohort Study and Offspring Follow-up (CPWCSaOF)

Xuan Liu,
Guangliang Shan,
Ping Huang,
Yu Jiang,
Yimin Qu,
Jian Zhao,
Tianchen Lyu,
Yunli Chen,
Yongle Zhan,
Yingjie Shi,
Hexin Yue,
Yaohan Meng,
Ao Jing,
Haihui Ma,
Dongmei Man,
Xiaoxiu Li,
Hongguo Wu

Affiliations

Xuan Liu: Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Guangliang Shan: Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China
Ping Huang: Department of Nutrition, First Affiliated Hospital of Nanchang University, Nanchang, China
Yu Jiang: Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Yimin Qu: Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Jian Zhao: Department of Nutrition and Food Safety, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Tianchen Lyu: Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Yunli Chen: Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Yongle Zhan: Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Yingjie Shi: Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Hexin Yue: Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Yaohan Meng: Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Ao Jing: Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Haihui Ma: Department of Obstetrics, Tongzhou Maternal and Child Health Hospital of Beijing, Beijing, China
Dongmei Man: Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, China
Xiaoxiu Li: Department of Pediatric Gastroenterology, Dongguan Maternal and Child Health Care Hospital, Dongguan, China
Hongguo Wu: Department of Perinatal Health, Jiaxian Maternal and Child Health Care Hospital, Jiaxian, China

DOI: https://doi.org/10.1136/bmjopen-2020-044933
Journal volume & issue: Vol. 11, no. 3

Abstract

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Purpose A multicentre prospective cohort study, known as the Chinese Pregnant Women Cohort Study (CPWCS), was established in 2017 to collect exposure data during pregnancy (except environmental exposure) and analyse the relationship between lifestyle during pregnancy and obstetric outcomes. Data about mothers and their children’s life and health as well as children’s laboratory testing will be collected during the offspring follow-up of CPWCS, which will enable us to further investigate the longitudinal relationship between exposure in different periods (during pregnancy and childhood) and children’s development.Participants 9193 pregnant women in 24 hospitals in China who were in their first trimester (5–13 weeks gestational age) from 25 July 2017 to 26 November 2018 were included in CPWCS by convenience sampling. Five hospitals in China which participated in CPWCS with good cooperation will be selected as the sample source for the Chinese Pregnant Women Cohort Study (Offspring Follow-up) (CPWCS-OF).Findings to date Some factors affecting pregnancy outcomes and health problems during pregnancy have been discovered through data analysis. The details are discussed in the ‘Findings to date’ section.Future plans Infants and children and their mothers who meet the criteria will be enrolled in the study and will be followed up every 2 years. The longitudinal relationship between exposure (questionnaire data, physical examination and biospecimens, medical records, and objective environmental data collected through geographical information system and remote sensing technology) in different periods (during pregnancy and childhood) and children’s health (such as sleeping problem, oral health, bowel health and allergy-related health problems) will be analysed.Trail registration number CPWCS was registered with ClinicalTrials.gov on 18 January 2018: NCT03403543. CPWCS-OF was registered with ClinicalTrials.gov on 24 June 2020: NCT04444791.

Published in BMJ Open

ISSN: 2044-6055 (Online)
Publisher: BMJ Publishing Group
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://bmjopen.bmj.com

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