Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration

Yeonjoo Kim; Jiyoung Lee; Maisa Seppala; Martyn T. Cobourne; Soo-Hyun Kim

doi:10.1038/s41467-020-15897-3

Nature Communications (Apr 2020)

Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration

Yeonjoo Kim,
Jiyoung Lee,
Maisa Seppala,
Martyn T. Cobourne,
Soo-Hyun Kim

Affiliations

Yeonjoo Kim: Molecular and Clinical Sciences Research Institute, St. George’s, University of London
Jiyoung Lee: Molecular and Clinical Sciences Research Institute, St. George’s, University of London
Maisa Seppala: Centre for Craniofacial and Regenerative Biology, Faculty of Dental, Oral and Craniofacial Sciences King’s College London Floor 27, Guy’s Hospital
Martyn T. Cobourne: Centre for Craniofacial and Regenerative Biology, Faculty of Dental, Oral and Craniofacial Sciences King’s College London Floor 27, Guy’s Hospital
Soo-Hyun Kim: Molecular and Clinical Sciences Research Institute, St. George’s, University of London

DOI: https://doi.org/10.1038/s41467-020-15897-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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How co-receptors Gas1 and Boc interact with Ptch1/2 receptors and regulate Hh signalling is unclear. Here, the authors demonstrate that the spatiotemporal expression of Gas1 and Boc determines how Hh signalling affects the dynamic migration of murine primordial germ cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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