Nature Communications (Oct 2022)
Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy
- Haitao Liu,
- Nadezda A. Stepicheva,
- Sayan Ghosh,
- Peng Shang,
- Olivia Chowdhury,
- Rachel A. Daley,
- Meysam Yazdankhah,
- Urvi Gupta,
- Stacey L. Hose,
- Mallika Valapala,
- Christopher Scott Fitting,
- Anastasia Strizhakova,
- Yang Shan,
- Derrick Feenstra,
- José-Alain Sahel,
- Ashwath Jayagopal,
- James T. Handa,
- J. Samuel Zigler,
- Patrice E. Fort,
- Akrit Sodhi,
- Debasish Sinha
Affiliations
- Haitao Liu
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Nadezda A. Stepicheva
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Sayan Ghosh
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Peng Shang
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Olivia Chowdhury
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Rachel A. Daley
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Meysam Yazdankhah
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Urvi Gupta
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Stacey L. Hose
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Mallika Valapala
- School of Optometry, Indiana University
- Christopher Scott Fitting
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Anastasia Strizhakova
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Yang Shan
- Kellogg Eye Center, University of Michigan School of Medicine
- Derrick Feenstra
- Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd.
- José-Alain Sahel
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- Ashwath Jayagopal
- Opus Genetics
- James T. Handa
- The Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- J. Samuel Zigler
- The Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- Patrice E. Fort
- Kellogg Eye Center, University of Michigan School of Medicine
- Akrit Sodhi
- The Wilmer Eye Institute, The Johns Hopkins University School of Medicine
- Debasish Sinha
- Department of Ophthalmology, University of Pittsburgh School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33773-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Retinal pigment epithelium (RPE) plays an important role in diabetic retinopathy (DR) progression. Here, the authors show AKT1 and AKT2 are reciprocally regulated in the RPE of DR donor tissue and diabetic mice, reducing Akt2 in RPE causing a compensatory increase in Akt1 and attenuating DR.
