Green and Efficient Construction of Chromeno[3,4-<i>c</i>]pyrrole Core via Barton–Zard Reaction from 3-Nitro-2<i>H</i>-chromenes and Ethyl Isocyanoacetate
Ivan A. Kochnev,
Alexey Y. Barkov,
Nikolay S. Zimnitskiy,
Vladislav Y. Korotaev,
Vyacheslav Y. Sosnovskikh
Affiliations
Ivan A. Kochnev
Institute of Natural Sciences and Mathematics, Ural Federal University, 620000 Ekaterinburg, Russia
Alexey Y. Barkov
Institute of Natural Sciences and Mathematics, Ural Federal University, 620000 Ekaterinburg, Russia
Nikolay S. Zimnitskiy
Institute of Natural Sciences and Mathematics, Ural Federal University, 620000 Ekaterinburg, Russia
Vladislav Y. Korotaev
Institute of Natural Sciences and Mathematics, Ural Federal University, 620000 Ekaterinburg, Russia
Vyacheslav Y. Sosnovskikh
Institute of Natural Sciences and Mathematics, Ural Federal University, 620000 Ekaterinburg, Russia
A regioselective one-pot method for the synthesis of 1-ethyl 2,4-dihydrochromene[3,4-c]pyrroles in 63–94% yields from available 2-phenyl-, 2-trifluoro(trichloro)methyl- or 2-phenyl-2-(trifluoromethyl)-3-nitro-2H-chromenes and ethyl isocyanoacetate through the Barton–Zard reaction in ethanol at reflux for 0.5 h, using K2CO3 as a base, has been developed.
