Effect of urea and tmao on lipid bilayers

Valerio J.; Bernstorff S.; Funari S.S.

doi:10.1515/afpuc-2017-0003

European Pharmaceutical Journal (Nov 2017)

Effect of urea and tmao on lipid bilayers

Valerio J.,
Bernstorff S.,
Funari S.S.

Affiliations

Valerio J.: Photo Science at DESY, Hamburg, Germany
Bernstorff S.: Elettra-Sincrotrone Trieste S.C.p.A, Trieste, Italy
Funari S.S.: Photo Science at DESY, Hamburg, Germany

DOI: https://doi.org/10.1515/afpuc-2017-0003
Journal volume & issue: Vol. 64, no. 2
pp. 24 – 27

Abstract

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We study the effect of the osmolytes, Urea and trimethylamine-N-oxide (TMAO) on POPE (1-palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine) lipid membranes using SAXS/WAXS and DSC. Their antagonist effect is observed with TMAO stabilizing and Urea destabilizing the lipid bilayer, as seen by others in earlier researches.

lipid membranes - phase transitions - osmocytes - x-rays - dsc

Published in European Pharmaceutical Journal

ISSN: 2453-6725 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://sciendo.com/journal/AFPUC

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Abstract

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