Nature Communications (Apr 2021)

The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones

  • Netta Shemesh,
  • Juman Jubran,
  • Shiran Dror,
  • Eyal Simonovsky,
  • Omer Basha,
  • Chanan Argov,
  • Idan Hekselman,
  • Mehtap Abu-Qarn,
  • Ekaterina Vinogradov,
  • Omry Mauer,
  • Tatiana Tiago,
  • Serena Carra,
  • Anat Ben-Zvi,
  • Esti Yeger-Lotem

DOI
https://doi.org/10.1038/s41467-021-22369-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Tissue-specific differences in protein folding capacities are poorly understood. Here, the authors show that the human chaperone system consists of ubiquitous core chaperones and tissue-specific variable chaperones, perturbation of which leads to tissue-specific phenotypes.