Frontiers in Cardiovascular Medicine (Aug 2023)

Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis

  • Xiaoyi Qi,
  • Xiaoyi Qi,
  • Shijia Wang,
  • Liangxian Qiu,
  • Xiongbiao Chen,
  • Qianwen Huang,
  • Kunfu Ouyang,
  • Yanjun Chen

DOI
https://doi.org/10.3389/fcvm.2023.1192664
Journal volume & issue
Vol. 10

Abstract

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BackgroundAlthough observational studies have shown that patients who experienced transient ischemic attacks (TIAs) had a higher risk of coronary artery disease (CAD), the causal relationship is ambiguous.MethodsWe conducted a two-sample Mendelian randomization (MR) study to analyze the causal relationship between TIA and CAD using data from the FinnGen genome-wide association study. Analysis was performed using the inverse-variance weighted (IVW) method. The robustness of the results was evaluated using MR-Egger regression, the weighted median, MR pleiotropy residual sum, and outlier (MR-PRESSO) and multivariable MR analysis.ResultsResults from IVW random-effect model showed that TIA was associated with an increased risk of coronary artery atherosclerosis (OR 1.17, 95% CI 1.06–1.28, P = 0.002), ischemic heart disease (OR 1.15, 95% CI 1.04–1.27, P = 0.007), and myocardial infarction (OR1.15, 95% CI 1.02–1.29, P = 0.025). In addition, heterogeneity and horizontal pleiotropy were observed in the ischemic heart disease results, while the sensitivity analysis revealed no evidence of horizontal pleiotropy in other outcomes.ConclusionsThis MR study demonstrated a potential causal relationship between TIA and CAD. Further research should be conducted to investigate the mechanism underlying the association.

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