JADA Foundational Science (Jan 2024)

Effect of scaling and root planing with and without minocycline hydrochloride microspheres on serum biomarkers and acute phase reactantsWhy Is This Important?

  • Michelle C. Arnett, MS, RDH,
  • Massimo Costalonga, DMD, PhD,
  • Phonsuda Chanthavisouk, MDT, BSDH,
  • Michael D. Evans, MS,
  • Danna R. Paulson, MSDH, RDH, CCRP

Journal volume & issue
Vol. 3
p. 100040

Abstract

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Background: This study tests the effects of scaling and root planing (SRP) vs SRP with minocycline hydrochloride microspheres (MMs) (SRP with MM) on serum biomarkers interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and matrix metalloproteinase-8 and acute phase reactants hemoglobin A1c (HbA1c), high-sensitivity C-reactive proteins and haptoglobin (Hp) in patients with stage II-IV grade B periodontitis. Methods: Seventy participants were randomized to receive SRP (n = 35) or SRP+MM (n = 35). Serum was collected at baseline (before SRP), 1-month reevaluation visit, and 3- and 6-month periodontal maintenance visits. MMs were delivered to pockets 5 mm or larger immediately after SRP and immediately after the 3-month periodontal maintenance visit. Serum for acute phase reactants only was collected at the 9- and 12-month posttreatment follow-up. All outcomes were summarized using estimated marginal means back-transformed to the original response scale with 95% CIs. Results: At 6 months, no statistical significance was yielded in either group for IL-6 (P = .91), tumor necrosis factor-α (P = .34), or matrix metalloproteinase-8 (P = .34). IL-1β (P = .06) was slightly higher in the SRP-alone group, suggesting a clinical impact with the addition of MM. Acute phase reactants were not statistically significant for high-sensitivity C-reactive proteins (P = .59), HbA1c (P = .46), or haptoglobin (P = .22) for either group. These outcomes continued at the 9- and 12-month posttreatment follow-up. Conclusions: SRP alone and SRP+MM minimally reduced levels of cytokine biomarkers and acute phase reactants in self-reported systemically healthy patients with advanced stages of periodontitis. Thresholds for resolution of local clinical inflammation may not have been achieved in this study to result in a reduction of systemic inflammation.

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